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Throughout the 1980s, there was a set of studies that seemingly found something very interesting: people who ate more beta-carotene-rich fruits and vegetables appeared to get less lung cancer. The logic was appealing - beta-carotene is an antioxidant and a precursor to vitamin A, which would be a plausible way
science-news
One of the central questions in neurodegenerative disease revolves around timing. Proteins such as amyloid-β, tau, and α-synuclein are always present inside of our cells, yet for most of our lives they remain stable and perform their normal functions. For some people, usually later in life, these proteins can start
solar
I’ve often heard that it is good to clean your solar panels once in a while, with many companies offering yearly services to come over and clean them for you. This has always been a bit of a dubious story to me; my panels still produce a lot of
Recently, in a journal club, we discussed the paper Endoplasmic Reticulum Stress Mediates Axon Initial Segment Shortening: Implications for Diabetic Brain Complications (Shelby et al., 2026), and something in Figure 2C and 2D caught my eye. In the paper, they compare the length of axon initial segments (AIS), which are
I wrote about making a L'Oaf AI and learning strategies from it a week or so ago. In the article I mentioned letting readers play against the AI, and after getting permission from the game's designer, Bart de Jong, I was able to put something together
simulations
Modeling in climate science is a complicated topic. These models have to do very difficult tasks - modeling climate, and are expected to inform future directions of climate change, air pollution, nitrogen deposition, and other questions that have huge consequences. The only way to deal with systems this complex is
skeptic
I was watching a Mrwhosetheboss Youtube video in which he showed off some Korean tech, including a red-light scalp massager. While watching I was getting a bit annoyed, as he pretty much just parroted the sales pitch of the red-light craze. It goes a little like this: shining certain wavelengths
l'oaf
For E. coli, the trick is chemosensing: it swims in straight runs, occasionally tumbles around, and biases that run-tumble pattern so it slowly gets closer to a food source. It does this by trying to increase the amount of gradient it senses, ie. following the attractant gradient. There's
simulations
Teaching an AI to play L'oaf and seeing what a human can learn from it.
science-news
I was interested in learning about the scientific core of Genmab’s business model. Looking for this, I found two key papers: the 2013 controlled Fab-arm exchange paper and the 2013 scale-up and manufacturing paper. The conceptual origin sits a bit earlier, in the IgG4 literature, where Fab-arm exchange shows
model
If you ask why we age, you can easily end up in the weeds of mitochondria, telomeres, senescent cells, cancer suppression, and a dozen other mechanisms that sound like the culprit. Biology offers many proximate causes of decline, and it is tempting to treat them as competing explanations. The risk